Dosage assessment of valnemulin in pigs based on population pharmacokinetic and Monte Carlo simulation. Issue 4 (21st January 2015)

• Record Type: Journal Article
• Authors: Yuan, L. G.; Tang, Y. Z.; Zhang, Y. X.; Sun, J.; Luo, X. Y.; Zhu, L. X.; Zhang, Z.; Wang, R.; Liu, Y. H.
• Is Part Of: Journal of veterinary pharmacology and therapeutics. Volume 38:Issue 4(2015)
• Page Start: 400
• Page End: 409
• Publication Date: 2015-01-21
• Subjects: Veterinary pharmacology -- Periodicals; Therapeutics -- Periodicals; 636.0895105
• DOI: 10.1111/jvp.12199
• Languages: English
• ISSNs: 0140-7783

Abstract

<abstract abstract-type="main" id="jvp12199-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>To estimate the valnemulin pharmacokinetic profile in a swine population and to assess a dosage regimen for increasing the likelihood of optimization. This study was, respectively, performed in 22 sows culled by p.o. administration and in 80 growing‐finishing pigs by i.v. administration at a single dose of 10 mg/kg to develop a population pharmacokinetic model and Monte Carlo simulation. The relationships among the plasma concentration, dose, and time of valnemulin in pigs were illustrated as <italic>C</italic><sub><italic>i</italic>, <italic>v</italic></sub> = <italic>X</italic><sub>0</sub>(8.4191 × 10<sup>‐4</sup> × <italic>e</italic><sup>−0.2371<italic>t</italic></sup> + 1.2788 × 10<sup>−5</sup> × <italic>e</italic><sup>−0.0069<italic>t</italic></sup>) after i.v. and <italic>C</italic><sub><italic>p</italic>.<italic>o</italic></sub> = <italic>X</italic><sub>0</sub>(−8.4964 × 10<sup>−4</sup> × <italic>e</italic><sup>−0.5840<italic>t</italic></sup> + 8.4195 × <italic>e</italic><sup>−0.2371<italic>t</italic></sup> + 7.6869 × 10<sup>−6</sup> × <italic>e</italic><sup>−0.0069<italic>t</italic></sup>) after p.o. Monte Carlo simulation showed that T<sub>></sub><sub>MIC</sub> was more than 24 h when a single daily dosage at 13.5 mg/kg BW in pigs was administrated by p.o., and MIC was 0.031 mg/L. It was concluded that the current dosage regimen at 10–12 mg/kg BW led to valnemulin underexposure if the MIC was more than 0.031 mg/L and could increase the risk of treatment failure and/or drug resistance.</p> </abstract>