Enantioselective pharmacokinetics of ketoprofen in calves after intramuscular administration of a racemic mixture. Issue 4 (20th November 2014)

• Record Type: Journal Article
• Authors: Plessers, E.; Watteyn, A.; Wyns, H.; Pardon, B.; De Baere, S.; De Backer, P.; Croubels, S.
• Is Part Of: Journal of veterinary pharmacology and therapeutics. Volume 38:Issue 4(2015)
• Page Start: 410
• Page End: 413
• Publication Date: 2014-11-20
• Subjects: Veterinary pharmacology -- Periodicals; Therapeutics -- Periodicals; 636.0895105
• DOI: 10.1111/jvp.12186
• Languages: English
• ISSNs: 0140-7783

Abstract

<abstract abstract-type="main" id="jvp12186-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>The pharmacokinetic properties of ketoprofen were determined in 4‐week‐old calves after intramuscular (i.m.) injection of a racemic mixture at a dose of 3 mg/kg body weight. Due to possible enantioselective disposition kinetics and chiral inversion, the plasma concentrations of the R(−) and S(+) enantiomer were quantified separately, using a stereospecific HPLC‐UV assay. A distinct predominance of the S(+) enantiomer was observed, as well as significantly different pharmacokinetic parameters between R(−) and S(+) ketoprofen. More in specific, a greater value for the mean area under the plasma concentration–time curve (AUC_0→∞) (46.92 ± 7.75 and 11.13 ± 2.18 μg·h/mL for the S(+) and R(−) enantiomer, respectively), a lower apparent clearance (Cl/F) (32.8 ± 5.7 and 139.0 ± 25.1 mL/h·kg for the S(+) and R(−) enantiomer, respectively) and a lower apparent volume of distribution (V_d/F) (139 ± 14.7 and 496 ± 139.4 mL/kg for the S(+) and R(−) enantiomer, respectively) were calculated for the S(+) enantiomer, indicating enantioselective pharmacokinetics for ketoprofen in calves following i.m. administration.</p> </abstract>