A lipidated form of the extracellular domain of influenza M2 protein as a self-adjuvanting vaccine candidate. Issue 30 (9th July 2015)

• Record Type: Journal Article
• Authors: Zeng, Weiguang; Tan, Amabel C.L.; Horrocks, Kylie; Jackson, David C.
• Is Part Of: Vaccine. Volume 33:Issue 30(2015)
• Page Start: 3526
• Page End: 3532
• Publication Date: 2015-07-09
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.05.053
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Lipopeptides based on the extracellular domain of influenza M2 protein constructed.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Immunization of the lipopeptides protects mice against lethal viral challenge.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Higher IgA and IgG2b antibodies in BAL by the i.n. immunization than the s.c. route.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">i.n. immunization protects mice better against viral challenge than by s.c. route.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Viral challenge boosts anti-M2e antibody specificity introduced by M2e immunization.</p> </list-item> </list> </p> </sec> </abstract>