Haematopoietic depletion in vaccine-induced neonatal pancytopenia depends on both the titre and specificity of alloantibody and levels of MHC I expression. Issue 30 (9th July 2015)

• Record Type: Journal Article
• Authors: Bell, Charlotte R.; MacHugh, Niall D.; Connelley, Timothy K.; Degnan, Kathryn; Morrison, W. Ivan
• Is Part Of: Vaccine. Volume 33:Issue 30(2015)
• Page Start: 3488
• Page End: 3496
• Publication Date: 2015-07-09
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.05.069
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">MHC I-specific alloantibodies play a dominant role in Bovine Neonatal Pancytopenia.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">50% of Pregsure-vaccinated cows produce MDBK-MHC I-specific alloantibodies.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Pregsure-vaccinated cows produce variable titres and specificities of alloantibody.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Alloantibody damage to haematopoietic cells is due to their high MHC I expression.</p> </list-item> </list> </p> </sec> </abstract>