A novel linear neutralizing epitope of hepatitis E virus. Issue 30 (9th July 2015)

• Record Type: Journal Article
• Authors: Tang, Zi-Min; Tang, Ming; Zhao, Min; Wen, Gui-Ping; Yang, Fan; Cai, Wei; Wang, Si-Ling; Zheng, Zi-Zheng; Xia, Ning-Shao
• Is Part Of: Vaccine. Volume 33:Issue 30(2015)
• Page Start: 3504
• Page End: 3511
• Publication Date: 2015-07-09
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.05.065
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">A novel neutralizing epitope L2 of HEV was identified.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The novel epitope is located in a.a. 423–437 of HEV pORF2.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Epitope L2 is non-immunodominant in both infection and vaccination process.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">We displayed epitope L2 on HBc149 protein and constructed HBcL2 particles.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">Immunization with HBcL2 stimulated anti-HEV neutralization <italic>in vivo</italic>.</p> </list-item> </list> </p> </sec> </abstract>