Pigs immunized with Chinese highly pathogenic PRRS virus modified live vaccine are protected from challenge with North American PRRSV strain NADC-20. Issue 30 (9th July 2015)

• Record Type: Journal Article
• Authors: Galliher-Beckley, Amy; Li, Xiangdong; Bates, John T.; Madera, Rachel; Waters, Andrew; Nietfeld, Jerome; Henningson, Jamie; He, Dongsheng; Feng, Wenhai; Chen, Ruiai; Shi, Jishu
• Is Part Of: Vaccine. Volume 33:Issue 30(2015)
• Page Start: 3518
• Page End: 3525
• Publication Date: 2015-07-09
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.05.058
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">We found that JXA-1R MLV vaccine can protect pigs from HP-PRRSV challenge in a U.S. setting.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">We also found that JXA-1R can protect pigs from NA circulating PRRSV NADC-20 challenge.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Protection may be due to JXA-1R-induced broadly neutralizing antibodies and enhanced pulmonary IFN-α/β production.</p> </list-item> </list> </p> </sec> </abstract>