Prevalence of HLA‐B*57:01 allele in Argentinean HIV‐1 infected patients. Issue 1 (29th April 2015)

• Record Type: Journal Article
• Authors: Moragas, M.; Belloso, W. H.; Baquedano, M. S.; Gutierrez, M. I.; Bissio, E.; Larriba, J. M.; Fay, F.; Aulicino, P.; Gurevich, J. M.; Yaunguzian, M. F.; Maldonado, A. C.; Falistocco, C.; Sen, L.; Mangano, A.
• Is Part Of: Tissue antigens. Volume 86:Issue 1(2015)
• Page Start: 28
• Page End: 31
• Publication Date: 2015-04-29
• Subjects: Antigens -- Periodicals; Immunological tolerance -- Periodicals; Immunogenetics -- Periodicals; 571.9645
• DOI: 10.1111/tan.12575
• Languages: English
• ISSNs: 0001-2815

Abstract

<abstract abstract-type="main" id="tan12575-abs-0001"> <title>Abstract</title> <p id="tan12575-para-0001">Hypersensitivity reaction to abacavir (ABC hypersensitivity syndrome, AHS) is strongly associated with the presence of the <italic>HLA‐B*57:01</italic> allele. This study was designed to estimate the prevalence of <italic>HLA‐B*57:01</italic> allele in Argentinean HIV‐1 infected patients. We analyzed the presence of <italic>HLA‐B*57:01</italic> allele in 1646 HIV‐1 infected patients from different regions of Argentina. This allele was detected in 81 patients; most of them corresponded to patients living in the central region of the country. The prevalence of <italic>HLA‐B*57:01</italic> was 4.9%, similar to other Caucasian populations and higher than other data reported for South American populations. This strongly supports screening for the presence of <italic>HLA‐B*57:01</italic> in abacavir treatment of HIV‐1 in our country.</p> </abstract>