Attenuated Age‐Related Increases in Arterial Stiffness in Japanese and American Women. Issue 6 (1st June 2015)

• Record Type: Journal Article
• Authors: Tanaka, Hirofumi; Miyachi, Motohiko; Murakami, Haruka; Maeda, Seiji; Sugawara, Jun
• Is Part Of: Journal of the American Geriatrics Society. Volume 63:Issue 6(2015:Jun.)
• Page Start: 1170
• Page End: 1174
• Publication Date: 2015-06-01
• Subjects: Geriatrics -- Periodicals; 618.97
• DOI: 10.1111/jgs.13433
• Languages: English
• ISSNs: 0002-8614

Abstract

<abstract abstract-type="main" id="jgs13433-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jgs13433-sec-0001" sec-type="section"> <title>Background</title> <p>The United States and Japan have similar standards of living, healthcare systems, and industrializations but exhibit markedly divergent life expectancies both at birth and at later ages (50 or 65 years old). Arterial stiffness has been widely regarded as a barometer of biological or physiological aging and could provide insight into the inter‐country differences.</p> </sec> <sec id="jgs13433-sec-0002" sec-type="section"> <title>Objectives</title> <p>To determine whether the increases in arterial stiffness across the adult age range are greater in U.S. than Japanese adults.</p> </sec> <sec id="jgs13433-sec-0003" sec-type="section"> <title>Design</title> <p>Cross‐sectional analyses.</p> </sec> <sec id="jgs13433-sec-0004" sec-type="section"> <title>Setting</title> <p>Laboratory‐based study.</p> </sec> <sec id="jgs13433-sec-0005" sec-type="section"> <title>Participants</title> <p>Healthy, nonsmoking Japanese (n = 400) and U.S. (n = 400) adults without cardiovascular and other chronic diseases.</p> </sec> <sec id="jgs13433-sec-0006" sec-type="section"> <title>Measurements</title> <p>Indices of arterial stiffness, including carotid‐femoral (cfPWV) and brachial‐ankle pulse wave velocity (baPWV) were measured, along with a variety of ancillary measures. The recruitment method, measurement technique, and protocol were standardized and identical between U.S. and Japanese facilities.</p> </sec> <sec id="jgs13433-sec-0007" sec-type="section"> <title>Results</title> <p>cfPWV and baPWV increased progressively with advancing age in all subgroups (stratified according to sex and country). The rates of age‐related increases in arterial stiffness were not different between U.S. and Japanese men, but age‐associated increases in cfPWV were significantly greater in U.S. than Japanese women, widening the intercountry differences at older age ranges.</p> </sec> <sec id="jgs13433-sec-0008" sec-type="section"> <title>Conclusion</title> <p>Japanese women had smaller increases in central arterial stiffness with advancing age than U.S. women.</p> </sec> </abstract>