Association Between Glycosylated Hemoglobin and Cardiovascular Events and Mortality in Older Adults without Diabetes Mellitus in the General Population: The Leiden 85‐Plus Study. Issue 6 (1st June 2015)

• Record Type: Journal Article
• Authors: Birkenhäger‐Gillesse, Elizabeth G.; den Elzen, Wendy P. J.; Achterberg, Wilco P.; Mooijaart, Simon P.; Gussekloo, Jacobijn; de Craen, Anton J. M.
• Is Part Of: Journal of the American Geriatrics Society. Volume 63:Issue 6(2015:Jun.)
• Page Start: 1059
• Page End: 1066
• Publication Date: 2015-06-01
• Subjects: Geriatrics -- Periodicals; 618.97
• DOI: 10.1111/jgs.13457
• Languages: English
• ISSNs: 0002-8614

Abstract

<abstract abstract-type="main" id="jgs13457-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jgs13457-sec-0001" sec-type="section"> <title>Objectives</title> <p>To examine the association between glycosylated hemoglobin (HbA1c) and incident cardiovascular disease and mortality in 85‐year‐old individuals without diabetes mellitus from the general population.</p> </sec> <sec id="jgs13457-sec-0002" sec-type="section"> <title>Design</title> <p>Population‐based prospective follow‐up study.</p> </sec> <sec id="jgs13457-sec-0003" sec-type="section"> <title>Setting</title> <p>General population.</p> </sec> <sec id="jgs13457-sec-0004" sec-type="section"> <title>Participants</title> <p>Individuals without known diabetes mellitus (N = 445, n = 291 female).</p> </sec> <sec id="jgs13457-sec-0005" sec-type="section"> <title>Measurements</title> <p>HbA1c levels were categorized into three groups (<5.0% (31 mmol/mol), 5.0–5.7% (31–39 mmol/mol; reference), 5.7–6.5% (39–48 mmol/mol)).</p> </sec> <sec id="jgs13457-sec-0006" sec-type="section"> <title>Results</title> <p>At baseline, a history of myocardial infarction (MI) was more prevalent in subjects in the highest HbA1c group (18%) than in the reference group (7%) (<italic>P</italic> = .001). Prospectively, those with the highest level of HbA1c at baseline had a risk of incident MI during the 5‐year follow‐up that was 3.6 (95% confidence interval = 1.5–8.3) times as great as that of the reference group. No association was found between HbA1c level and incident stroke, cardiovascular mortality, or all‐cause mortality.</p> </sec> <sec id="jgs13457-sec-0007" sec-type="section"> <title>Conclusion</title> <p>In individuals aged 85 and older without diabetes mellitus, higher HbA1c is associated with greater risk of MI but not with stroke and mortality.</p> </sec> </abstract>