<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>The novel one‐pot multicomponent reaction is based on the reaction of N‐alkyl‐N‐(1H‐indol‐2‐ylmethyl)amines, with various carbonyl compounds, such as aldehydes including formaldehyde or cyclohexenone, and variously functionalized isocyanides.</p> </abstract>