Further Confirmation of Germline Glioma Risk Variant rs78378222 in TP53 and Its Implication in Tumor Tissues via Integrative Analysis of TCGA Data. Issue 7 (18th May 2015)

• Record Type: Journal Article
• Authors: Wang, Zhaoming; Rajaraman, Preetha; Melin, Beatrice S.; Chung, Charles C.; Zhang, Weijia; McKean‐Cowdin, Roberta; Michaud, Dominique; Yeager, Meredith; Ahlbom, Anders; Albanes, Demetrius; Andersson, Ulrika; Freeman, Laura E. Beane; Buring, Julie E.; Butler, Mary Ann; Carreón, Tania; Feychting, Maria; Gapstur, Susan M.; Gaziano, J. Michael; Giles, Graham G.; Hallmans, Goran; Henriksson, Roger; Hoffman‐Bolton, Judith; Inskip, Peter D.; Kitahara, Cari M.; Marchand, Loic Le; Linet, Martha S.; Li, Shengchao; Peters, Ulrike; Purdue, Mark P.; Rothman, Nathaniel; Ruder, Avima M.; Sesso, Howard D.; Severi, Gianluca; Stampfer, Meir; Stevens, Victoria L.; Visvanathan, Kala; Wang, Sophia S.; White, Emily; Zeleniuch‐Jacquotte, Anne; Hoover, Robert; Fraumeni, Joseph F.; Chatterjee, Nilanjan; Hartge, Patricia; Chanock, Stephen J.;
• Is Part Of: Human mutation. Volume 36:Issue 7(2015:Jul.)
• Page Start: 684
• Page End: 688
• Publication Date: 2015-05-18
• Subjects: Human chromosome abnormalities -- Periodicals; Mutation (Biology) -- Periodicals; 616.04205
• DOI: 10.1002/humu.22799
• Languages: English
• ISSNs: 1059-7794

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="humu22799-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>Imputation analysis of a genome‐wide association study (GWAS) of glioma confirmed a strong association of the germline risk variant: rs78378222 in 3′‐UTR of <italic>TP53</italic>. Further integrative analyses based on the Cancer Genome Atlas (TCGA) multi‐dimensional data suggest the rare risk allele (C) disrupts proper mRNA termination and an allelic loss of a genomic region encapsulating common protective allele (A) occurs during tumor initiation or progression for glioma. <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj11pwmwtn" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>