Relationship between 18-F-fluoro-deoxy-d-glucose uptake and expression of glucose transporter 1 and pyruvate kinase M2 in intrahepatic cholangiocarcinoma. Issue 7 (July 2015)

• Record Type: Journal Article
• Authors: Suzuki, Hideki; Komuta, Mina; Bolog, Altan; Yokobori, Takehiko; Wada, Satoshi; Araki, Kenichiro; Kubo, Norio; Watanabe, Akira; Tsukagoshi, Mariko; Kuwano, Hiroyuki
• Is Part Of: Digestive and liver disease. Volume 47:Issue 7(2015)
• Page Start: 590
• Page End: 596
• Publication Date: 2015-07
• Subjects: Digestive organs -- Diseases -- Periodicals; Liver -- Diseases -- Periodicals; 616.33005
• DOI: 10.1016/j.dld.2015.03.017
• Languages: English
• ISSNs: 1590-8658

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <title id="sect0010">Background</title> <p id="spar0005">Cholangiocellular carcinoma is characterized by elevated glucose consumption, resulting in an increased uptake of 18F-2-fluoro-2-deoxy-<sc>d</sc>-glucose (18F-FDG). This study investigates the relationship between 18F-FDG uptake and tumour glucose metabolism.</p> </sec> <sec> <title id="sect0015">Methods</title> <p id="spar0010">This was a retrospective analysis of 19 patients with cholangiocellular carcinoma. Immunohistochemistry for glucose transporter 1 and pyruvate kinase type M2 were performed. Overall tumour glucose metabolism was evaluated by measuring 18F-FDG uptake and the protein expression levels of glucose transporter 1 and pyruvate kinase type M2.</p> </sec> <sec> <title id="sect0020">Results</title> <p id="spar0015">18F-FDG uptake had a strong positive correlation with histological differentiation. Both tumour status (<italic>p</italic> = 0.044) and tumour size (<italic>p</italic> = 0.011) were correlated with primary tumour 18F-FDG uptake. Glucose transporter 1 expression correlated with histological differentiation (<italic>p</italic> = 0.017), while pyruvate kinase type M2 expression tended to correlate with lymph node metastasis (<italic>p</italic> = 0.051). Glucose transporter 1 expression was strongly related to the standard uptake value (<italic>p</italic> = 0.001), but that of pyruvate kinase type M2 was not (<italic>p</italic> = 0.461).</p> </sec> <sec> <title id="sect0025">Conclusions</title> <p id="spar0020">Glucose transporter 1 expression exhibits a strong correlation with 18F-FDG uptake in cholangiocellular carcinoma tissue, while pyruvate kinase type M2 expression was not associated with fluoro-2-deoxy-<sc>d</sc>-glucose uptake. In addition to its glycolytic function, pyruvate kinase type M2 has a variety of roles and its expression may enhance tumour cell invasion and promote the lymph node metastasis of intrahepatic cholangiocarcinoma.</p> </sec> </abstract>