The utility of fully automated real-time three-dimensional echocardiography in the evaluation of left ventricular diastolic function. Issue 1 (July 2015)

• Record Type: Journal Article
• Authors: Nakanishi, Koki; Fukuda, Shota; Watanabe, Hiroyuki; Seo, Yoshihiro; Mahara, Keitaro; Hyodo, Eiichi; Otsuka, Kenichiro; Ishizu, Tomoko; Shimada, Kenei; Sumiyoshi, Tetsuya; Aonuma, Kazutaka; Tomoike, Hitonobu; Yoshikawa, Junichi
• Is Part Of: Journal of cardiology. Volume 66:Issue 1(2015:Jul.)
• Page Start: 50
• Page End: 56
• Publication Date: 2015-07
• Subjects: Cardiology -- Periodicals; 616.12
• DOI: 10.1016/j.jjcc.2014.08.007
• Languages: English
• ISSNs: 0914-5087

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <title id="sect0010">Background</title> <p id="spar0005">A novel real-time three-dimensional echocardiography (RT3DE) system allows fully automated quantification of the left ventricular (LV) volume throughout a cardiac cycle. This study aimed to investigate whether an LV time–volume curve, obtained using fully automated RT3DE, is useful in the evaluation of LV diastolic function.</p> </sec> <sec> <title id="sect0015">Methods</title> <p id="spar0010">First, 15 patients underwent simultaneous standard two-dimensional echocardiography (2DE), RT3DE, and cardiac catheterization to measure the time constant of the isovolumic-pressure decline (<italic>τ</italic>). From the LV time–volume curve obtained using RT3DE, peak early filling rate (PFR) during diastole was generated and indexed for LV end-systolic volume. Next 570 patients, who were scheduled for both 2DE and RT3DE examinations, were enrolled to investigate the association between PFR index and 2DE-evidenced diastolic dysfunction and clinical characteristics.</p> </sec> <sec> <title id="sect0020">Results</title> <p id="spar0015">Of the 585 patients, RT3DE analysis was adequate in 542 patients (feasibility 93%). In the 15 patients, PFR index showed significant correlation with <italic>τ</italic> (<italic>r</italic> = −0.65, <italic>p</italic> = 0.009). In the remaining 527 patients, PFR index was related to age (<italic>r</italic> = −0.24, <italic>p</italic> < 0.001) and <italic>e</italic>′ (<italic>r</italic> = 0.41, <italic>p</italic> < 0.001). PFR index decreased in proportion to the grade of 2DE-evidenced diastolic dysfunction. All patients with normal diastolic function had a PFR index greater than 2.0.</p> </sec> <sec> <title id="sect0025">Conclusions</title> <p id="spar0020">This study demonstrated that a novel, fully automated RT3DE-derived PFR index was the diagnostic tool of choice for the assessment of LV diastolic function.</p> </sec> </abstract>