Increased extent of myocardial fibrosis in genotyped hypertrophic cardiomyopathy with ventricular tachyarrhythmias. Issue 1 (July 2015)

• Record Type: Journal Article
• Authors: Fujita, Takashi; Konno, Tetsuo; Yokawa, Junichiro; Masuta, Eiichi; Nagata, Yoji; Fujino, Noboru; Funada, Akira; Hodatsu, Akihiko; Kawashiri, Masa-aki; Yamagishi, Masakazu; Hayashi, Kenshi
• Is Part Of: Journal of cardiology. Volume 66:Issue 1(2015:Jul.)
• Page Start: 63
• Page End: 68
• Publication Date: 2015-07
• Subjects: Cardiology -- Periodicals; 616.12
• DOI: 10.1016/j.jjcc.2014.10.002
• Languages: English
• ISSNs: 0914-5087

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <title id="sect0010">Background</title> <p id="spar0005">Occurrence of malignant ventricular tachyarrhythmias such as ventricular tachycardia and fibrillation (VT/VF) in hypertrophic cardiomyopathy (HCM) can be related to the extent of myocardial fibrosis. Although late gadolinium enhancement (LGE) on cardiovascular magnetic resonance (CMR) imaging has been used to detect myocardial fibrosis, few data exist regarding relationships between CMR-determined myocardial fibrosis and VT/VF in genotyped HCM populations.</p> </sec> <sec> <title id="sect0015">Objective</title> <p id="spar0010">We retrospectively investigated whether the extent of LGE can be increased in HCM patients with VT/VF compared to those without VT/VF in the genotyped HCM population.</p> </sec> <sec> <title id="sect0020">Methods and results</title> <p id="spar0015">We studied 35 HCM patients harboring sarcomere gene mutations (<italic>TNNI3</italic> = 22, <italic>MYBPC3</italic> = 12, <italic>MYH7</italic> = 1) who underwent both CMR imaging and 24-h ambulatory electrocardiographic monitoring. VT/VF were identified in 6 patients (2 men, mean age 55.0 years). The extent of LGE was significantly increased in patients with VT/VF (<italic>n</italic> = 6) compared with those without VT/VF (<italic>n</italic> = 29) (18.6 ± 14.4% vs<italic>.</italic> 8.3 ± 11.4%, <italic>p</italic> = 0.04), although the LGE extent was not an independent predictor for the occurrence of VT/VF. Applying a cut-off point ≥3.25%, episodes of VT/VF were identified with a sensitivity of 100%, specificity of 51.7%, positive predictive value of 30%, negative predictive value of 100%, and the area under the curve of 0.767 (95% confidence interval: 0.590–0.944).</p> </sec> <sec> <title id="sect0025">Conclusion</title> <p id="spar0020">These results demonstrate that myocardial fibrosis determined by CMR imaging may be increased in genotyped HCM patients with episodes of VT/VF. A further prospective study will be needed to clarify the association between the LGE extent and arrhythmic events in HCM patients harboring sarcomere gene mutations.</p> </sec> </abstract>