Additional value of the red blood cell distribution width to the Mehran risk score for predicting contrast-induced acute kidney injury in patients with ST-elevation acute myocardial infarction. Issue 1 (July 2015)

• Record Type: Journal Article
• Authors: Mizuno, Atsushi; Ohde, Sachiko; Nishizaki, Yuji; Komatsu, Yasuhiro; Niwa, Koichiro
• Is Part Of: Journal of cardiology. Volume 66:Issue 1(2015:Jul.)
• Page Start: 41
• Page End: 45
• Publication Date: 2015-07
• Subjects: Cardiology -- Periodicals; 616.12
• DOI: 10.1016/j.jjcc.2014.09.006
• Languages: English
• ISSNs: 0914-5087

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <title id="sect0010">Background</title> <p id="spar0005">Contrast-induced acute kidney injury (CI-AKI) after percutaneous coronary intervention in patients with ST-elevation myocardial infarction (STEMI) is a common complication associated with worse outcome. Considering the prognostic predictive value of the red cell distribution width (RDW), we aimed to measure the usefulness of RDW for predicting CI-AKI.</p> </sec> <sec> <title id="sect0015">Methods</title> <p id="spar0010">All consecutive STEMI patients without hemodialysis from June 2011 to September 2013 admitted to St. Luke's International Hospital were enrolled. We performed primary percutaneous coronary intervention in all patients. CI-AKI was defined as a >25% increase or an absolute increase in serum creatinine of 0.5 mg/dl within 3 days after percutaneous coronary intervention. The potential additional predictive value of RDW with the Mehran risk score (MRS) on admission was estimated.</p> </sec> <sec> <title id="sect0020">Results</title> <p id="spar0015">A total of 102 patients (78.4% males) were analyzed – 10 of the 102 (10%) STEMI patients developed CI-AKI. Multivariate analysis showed that RDW was an independent variable predicting CI-AKI in these patients [odds ratio, 2.029; 95% confidence interval (95% CI), 1.029–3.999; <italic>p</italic> = 0.041]. The areas under the receiver operating characteristic curves for MRS only, RDW only, and the combined model (MRS and RDW) for the prediction of CI-AKI were 0.806 (95% CI, 0.696–0.917), 0.719 (95% CI, 0.536–0.902), and 0.846 (95% CI, 0.744–0.949), respectively.</p> </sec> <sec> <title id="sect0025">Conclusion</title> <p id="spar0020">We showed the potential predictive ability of RDW, only if used with MRS, for CI-AKI in STEMI patients. Further evaluation of RDW for predicting CI-AKI in patients with STEMI is needed.</p> </sec> </abstract>