Application of neutrophil/lymphocyte ratio in predicting coronary blood flow and mortality in patients with ST-elevation myocardial infarction undergoing percutaneous coronary intervention. Issue 1 (July 2015)

• Record Type: Journal Article
• Authors: Pan, Wei; Zhao, Deliang; Zhang, Canxiu; Li, Wenhua; Yu, Jiahui; Wang, Shu; Li, Zhuqin; Wang, Zhonghua; Sun, Xinyong; Liu, Hongwei; Sun, Yanming; Tian, Ye; Wang, Lanfeng
• Is Part Of: Journal of cardiology. Volume 66:Issue 1(2015:Jul.)
• Page Start: 9
• Page End: 14
• Publication Date: 2015-07
• Subjects: Cardiology -- Periodicals; 616.12
• DOI: 10.1016/j.jjcc.2014.10.014
• Languages: English
• ISSNs: 0914-5087

Abstract

<abstract abstract-type="author" id="abs0005"> <title id="sect0005">Abstract</title> <sec> <title id="sect0010">Background</title> <p id="spar0005">To investigate the potential correlation of neutrophil/lymphocyte ratio (NLR) to coronary blood flow and in-hospital along with long-term mortality in patients with ST-elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI).</p> </sec> <sec> <title id="sect0015">Methods</title> <p id="spar0010">In the current study, 636 consecutive patients with STEMI were recruited and stratified into three tertiles by NLRs upon admission (tertile I < 3.0, tertile II 3.0–6.40, tertile III > 6.40). The coronary blood flow was expressed by corrected TIMI frame count (CTFC). The in-hospital mortality and 12-month long follow-up data were collected. Receiver operating characteristic (ROC) curves were also constructed.</p> </sec> <sec> <title id="sect0020">Results</title> <p id="spar0015">Our analysis demonstrated that NLR was positively correlated to CTFC and in-hospital mortality (<italic>r</italic> = 0.517, <italic>p</italic> < 0.001; <italic>r</italic> = 0.439, <italic>p</italic> < 0.001). In the multiple logistic regression analysis, NLR was testified as an independent risk factor for coronary blood flow after PCI and in-hospital mortality [odds ratio (OR) = 2.031, 95% confidence interval (CI): 1.627–2.435, <italic>p</italic> < 0.001; OR = 1.176, 95% CI: 1.025–1.351, <italic>p</italic> = 0.021]. During the 12-month follow-up, there were a total of 43 deaths and statistically significant increase in long-term mortality was observed in patients from tertile I to III (<italic>p</italic> = 0.005). In the ROC curves analysis, the area under the curve (AUC = 0.607, 95% CI: 0.475–0.739, <italic>p</italic> = 0.253), with threshold value of 5.9 (sensitivity: 63.7%, specificity: 61.1%) for predicting in-hospital mortality.</p> </sec> <sec> <title id="sect0025">Conclusions</title> <p id="spar0020">NLR, an indicator that can be tested in the laboratory with low cost and time consumption, is independently correlated to coronary blood flow and acts as an independent risk factor for in-hospital mortality in patients with STEMI undergoing PCI.</p> </sec> </abstract>