Crystallization of Terutroban Sodium Salt Hydrate from the Deliquescent State. Issue 6 (8th April 2015)

• Record Type: Journal Article
• Authors: Couvrat, Nicolas; Cartigny, Yohann; Linol, Julie; Vaysse‐Ludot, Lucile; Langlois, Pascal; Coquerel, Gérard; Coquerel, Gerard; Couvrat, Nicolas; Cartigny, Yohann
• Is Part Of: Chemical engineering & technology. Volume 38:Issue 6(2015:Jun.)
• Page Start: 999
• Page End: 1005
• Publication Date: 2015-04-08
• Subjects: Chemical engineering -- Periodicals; Chemical processes -- Periodicals; 660.05
• DOI: 10.1002/ceat.201400692
• Languages: English
• ISSNs: 0930-7516

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Terutroban sodium salt (Teru‐Na) is a solid active pharmaceutical ingredient initially produced in its anhydrous form. The crystallization of a new dihydrate was established using liquid‐assisted grinding and the liquid‐liquid interface process. The stability of the Teru‐Na crystalline phases was investigated as a function of temperature and relative humidity. A combination of analytical tools (spectroscopic, thermal, and vapor sorption analyses) highlighted the remarkable stability of the dihydrate, in particular under variable storage conditions. A rationalization of the stability hierarchy was proposed by means of phase diagrams.</p> </abstract>