Silver(I)‐ or Copper(II)‐Mediated Dearomatization of Aromatic Ynones: Direct Access to Spirocyclic Scaffolds1. Issue 26 (8th May 2015)

• Record Type: Journal Article
• Authors: James, Michael J.; Cuthbertson, James D.; O'Brien, Peter; Taylor, Richard J. K.; Unsworth, William P.
• Is Part Of: Angewandte Chemie international edition. Volume 54:Issue 26(2015)
• Page Start: 7640
• Page End: 7643
• Publication Date: 2015-05-08
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201501812
• Languages: English
• ISSNs: 1433-7851

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>A high‐yielding silver(I)‐ or copper(II)‐catalyzed dearomatizing spirocyclization strategy allows the conversion of simple aromatic compounds that contain ynone substituents, including indole, anisole, pyrrole, and benzofuran derivatives, into functionalized spirocyclic scaffolds. A high‐yielding asymmetric variant furnishes spirocyclic indolenines in up to 89:11 e.r.</p> </abstract>