Direct ortho‐Hydroxylation of 2‐Phenylpyridines using Palladium(II) Chloride and Hydrogen Peroxide. Issue 9 (15th June 2015)

• Record Type: Journal Article
• Authors: Yamaguchi, Tomoaki; Yamaguchi, Eiji; Tada, Norihiro; Itoh, Akichika
• Is Part Of: Advanced synthesis & catalysis. Volume 357:Issue 9(2015)
• Page Start: 2017
• Page End: 2021
• Publication Date: 2015-06-15
• Subjects: Catalysis -- Periodicals; Organic compounds -- Synthesis -- Periodicals; Chemistry -- Periodicals; Chemistry, Technical -- Periodicals; Chemistry -- Periodicals; Catalysis -- Periodicals; Technology, Pharmaceutical -- Periodicals; 547.2
• DOI: 10.1002/adsc.201500061
• Languages: English
• ISSNs: 1615-4150

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Direct functionalization of the ubiquitous CH bond is receiving much attention because complex structures can be formed from simple precursors. This paper reports a useful method for the direct hydroxylation of 2‐phenylpyridines using palladium(II) chloride and aqueous hydrogen peroxide. In this method, hydrogen peroxide, which has high atom efficiency, is employed as the oxidant and phenol derivatives are generated <italic>via</italic> CH activation.</p> <p> <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgj10cp22xc" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /> </p> </abstract>