An immunophenotypic pre‐treatment predictor for poor response to induction chemotherapy in older acute myeloid leukaemia patients: blood frequency of CD34+ CD38low blasts. (14th April 2015)

• Record Type: Journal Article
• Authors: Khan, Naeem; Freeman, Sylvie D.; Virgo, Paul; Couzens, Steve; Richardson, Peter; Thomas, Ian; Grech, Angela; Vyas, Paresh; Grimwade, David; Russell, Nigel H.; Burnett, Alan K.; Hills, Robert K.
• Is Part Of: British journal of haematology. Volume 170:Number 1(2015:Jul.)
• Page Start: 80
• Page End: 84
• Publication Date: 2015-04-14
• Subjects: Hematology -- Periodicals; Blood -- Diseases -- Periodicals; 616.15
• DOI: 10.1111/bjh.13398
• Languages: English
• ISSNs: 0007-1048

Abstract

<abstract abstract-type="main" id="bjh13398-abs-0001"> <title>Summary</title> <p>Many older patients with acute myeloid leukaemia (AML) that receive standard intensive chemotherapy fail to achieve complete remission (CR). Upfront identification of patients unlikely to benefit from standard induction chemotherapy would be important for exploration of novel therapies. This study evaluated if a flow cytometric assay measuring pre‐treatment CD34⁺ CD38^low blast frequency could predict therapeutic‐resistance in 736 AML patients entered into the UK National Cancer Research Institute AML16 trial. High peripheral blood CD34⁺ CD38^low blast frequency (&gt;7% of leucocytes), present in 18% of assessable patients, conferred significantly reduced CR rates (38% vs. 76%, <italic>P</italic> &lt; 0·0001) and poor survival, and was independently prognostic for all endpoints of treatment resistance by multivariate analysis.</p> </abstract>