Telmisartan treatment targets inflammatory cytokines to suppress the pathogenesis of acute colitis induced by dextran sulphate sodium. Issue 2 (August 2015)

• Record Type: Journal Article
• Authors: Arumugam, Somasundaram; Sreedhar, Remya; Thandavarayan, Rajarajan A.; Giridharan, Vijayasree V.; Karuppagounder, Vengadeshprabhu; Pitchaimani, Vigneshwaran; Afrin, Mst. Rejina; Miyashita, Shizuka; Nomoto, Mayumi; Harima, Meilei; Suzuki, Hiroshi; Nakamura, Takashi; Nakamura, Masahiko; Suzuki, Kenji; Watanabe, Kenichi
• Is Part Of: Cytokine. Volume 74:Issue 2(2015)
• Page Start: 305
• Page End: 312
• Publication Date: 2015-08
• Subjects: Cytokines -- Periodicals; 571.844
• DOI: 10.1016/j.cyto.2015.03.017
• Languages: English
• ISSNs: 1043-4666

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st105">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0120">Intra-rectal treatment with telmisartan ameliorated DSS induced acute colitis mice.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0125">It has reduced the colonic proinflammatory cytokines expression in colitis mice.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0130">It has also reduced oxidative stress and endoplasmic reticulum stress.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0135">Further reduced the DNA damage along with the modulation of apoptosis signaling.</p> </list-item> </list> </p> </sec> </abstract>