Identification of pathway-based toxicity in the BALB/c 3T3 cell model. Issue 6 (September 2015)

• Record Type: Journal Article
• Authors: Vaccari, Monica; Mascolo, Maria Grazia; Rotondo, Francesca; Morandi, Elena; Quercioli, Daniele; Perdichizzi, Stefania; Zanzi, Cristina; Serra, Stefania; Poluzzi, Vanes; Angelini, Paola; Grilli, Sandro; Colacci, Annamaria
• Is Part Of: Toxicology in vitro. Volume 29:Issue 6(2015)
• Page Start: 1240
• Page End: 1253
• Publication Date: 2015-09
• Subjects: Toxicity testing -- In vitro -- Periodicals; Toxicology -- Periodicals; 615.9
• DOI: 10.1016/j.tiv.2014.10.002
• Languages: English
• ISSNs: 0887-2333

Abstract

<abstract xml:lang="en" abstract-type="author-highlights" id="ab005"> <title id="st120">Highlights</title> <sec> <p id="sp0005"> <list id="l0005"> <list-item id="o0005"> <label></label> <p id="p0365">Dose-related toxicity was evidenced in BALB/c 3T3 cells treated with PM_2.5 samples.</p> </list-item> <list-item id="o0010"> <label></label> <p id="p0370">Cell toxicity depended on PM_2.5 sampling season and sampling site.</p> </list-item> <list-item id="o0015"> <label></label> <p id="p0375">Gene pathways related to toxic stress response were identified in the treated cells.</p> </list-item> <list-item id="o0020"> <label></label> <p id="p0380">No foci formation was evidenced in the cell transformation assay.</p> </list-item> <list-item id="o0025"> <label></label> <p id="p0385">Gene pathways related to chronic lung diseases and cancer onset were modulated.</p> </list-item> </list> </p> </sec> </abstract>