Bevacizumab radiosensitizes non-small cell lung cancer xenografts by inhibiting DNA double-strand break repair in endothelial cells. Issue 1 (28th August 2015)

• Record Type: Journal Article
• Authors: Gao, Hui; Xue, Jianxin; Zhou, Lin; Lan, Jie; He, Jiazhuo; Na, Feifei; Yang, Lifei; Deng, Lei; Lu, You
• Is Part Of: Cancer letters. Volume 365:Issue 1(2015)
• Page Start: 79
• Page End: 88
• Publication Date: 2015-08-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.05.011
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Biweekly bevacizumab induces periodical vascular normalization in NSCLC xenograft model.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Radiosensitization induced by bevacizumab is not dependent on vascular normalization.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Bevacizumab inhibits DSBs' repair of ECs post irradiation, and promotes their apoptosis.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">Bevacizumab inhibits the activation of PI3K/Akt/DNA-PKcs signaling pathway post irradiation.</p> </list-item> </list> </p> </sec> </abstract>