Silencing of LRRFIP1 reverses the epithelial–mesenchymal transition via inhibition of the Wnt/β-catenin signaling pathway. Issue 1 (28th August 2015)

• Record Type: Journal Article
• Authors: Douchi, Daisuke; Ohtsuka, Hideo; Ariake, Kyohei; Masuda, Kunihiro; Kawasaki, Shuhei; Kawaguchi, Kei; Fukase, Koji; Oikawa, Masaya; Motoi, Fuyuhiko; Naitoh, Takeshi; Katayose, Yu; Egawa, Shinichi; Unno, Michiaki
• Is Part Of: Cancer letters. Volume 365:Issue 1(2015)
• Page Start: 132
• Page End: 140
• Publication Date: 2015-08-28
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.05.023
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">The role of LRRFIP1 in the EMT and invasion of carcinoma cells was investigated.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Repression of LRRFIP1 caused reversal of EMT and inhibited migration and invasion.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Silencing of LRRFIP1 regulated phosphorylation and nuclear localization of β-catenin.</p> </list-item> <list-item id="u0025"> <label></label> <p id="p0025">β-catenin expressed on the membrane was increased in LRRFIP1 silenced cancer cells.</p> </list-item> </list> </p> </sec> </abstract>