DNMT1 and EZH2 mediated methylation silences the microRNA-200b/a/429 gene and promotes tumor progression. Issue 2 (10th April 2015)

• Record Type: Journal Article
• Authors: Ning, Xianghong; Shi, Zhendong; Liu, Xi; Zhang, Anling; Han, Lei; Jiang, Kui; Kang, Chunsheng; Zhang, Qingyu
• Is Part Of: Cancer letters. Volume 359:Issue 2(2015)
• Page Start: 198
• Page End: 205
• Publication Date: 2015-04-10
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.01.005
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">EZH2 regulates the tri-methylation of H3K27 and reduces DNMT1 expression.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Knocking-down of DNMT1 down-regulates the components of the PRC2 (EZH2, SUZ12, EED) complex.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">EZH2 and DNMT1 inactivate the expression of mir-200b/a/429 cluster.</p> </list-item> </list> </p> </sec> </abstract>