Heat shock protein gp96 decreases p53 stability by regulating Mdm2 E3 ligase activity in liver cancer. Issue 2 (10th April 2015)

• Record Type: Journal Article
• Authors: Wu, Bo; Chu, Xiaoyu; Feng, Cong; Hou, Junwei; Fan, Hongxia; Liu, Ningning; Li, Changfei; Kong, Xianping; Ye, Xin; Meng, Songdong
• Is Part Of: Cancer letters. Volume 359:Issue 2(2015)
• Page Start: 325
• Page End: 334
• Publication Date: 2015-04-10
• Subjects: Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2015.01.034
• Languages: English
• ISSNs: 0304-3835

Abstract

<abstract abstract-type="author-highlights" id="ab0010"> <title id="st0010">Highlights</title> <sec> <p id="sp0010"> <list id="ulist0010"> <list-item id="u0010"> <label></label> <p id="p0010">Gp96 inhibits cell apoptosis and decreases p53 levels in liver cancer cells.</p> </list-item> <list-item id="u0015"> <label></label> <p id="p0015">Gp96 interacts with both p53 and Mdm2 to enhance Mdm2-mediated p53 ubiquitination and degradation.</p> </list-item> <list-item id="u0020"> <label></label> <p id="p0020">Gp96 knockdown greatly inhibited <italic>in vivo</italic> liver tumor growth and promoted apoptosis.</p> </list-item> </list> </p> </sec> </abstract>