Farnesyltransferase and geranylgeranyltransferase I: structures, mechanism, inhibitors and molecular modeling. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Shen, Mingyun; Pan, Peichen; Li, Youyong; Li, Dan; Yu, Huidong; Hou, Tingjun
• Is Part Of: Drug discovery today. Volume 20:Issue 2(2015)
• Page Start: 267
• Page End: 276
• Publication Date: 2015-02
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2014.10.002
• Languages: English
• ISSNs: 1359-6446

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Structures and therapeutic importance of FTase and GGTase-1 are briefly outlined.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Available inhibitors of FTase and GGTase-1 are systematically summarized.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Binding mechanisms of representative FTIs and GGTIs are described.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Recent applications of molecular modeling in the design of FTIs and GGTIs are discussed.</p> </list-item> </list> </p> </sec> </abstract>