Radionuclides in drug development. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Uhl, Philipp; Fricker, Gert; Haberkorn, Uwe; Mier, Walter
• Is Part Of: Drug discovery today. Volume 20:Issue 2(2015)
• Page Start: 198
• Page End: 208
• Publication Date: 2015-02
• Subjects: Drugs -- Design -- Periodicals; Drugs -- Research -- Periodicals; 615.1
• DOI: 10.1016/j.drudis.2014.09.027
• Languages: English
• ISSNs: 1359-6446

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Radiotracers are of prime importance for all stages of drug development.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">The main applications are target identification, pharmacokinetics and clinical trials.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Radiotracer methods include imaging, biodistribution and metabolism studies.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Modern applications include molecular imaging and first-in-human studies (microdosing).</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">They provide excellent prospects of improving stratification for personalized medicine.</p> </list-item> </list> </p> </sec> </abstract>