The impact of common and rare EGFR mutations in response to EGFR tyrosine kinase inhibitors and platinum-based chemotherapy in patients with non-small cell lung cancer. Issue 2 (February 2015)

• Record Type: Journal Article
• Authors: Arrieta, Oscar; Cardona, Andrés Felipe; Corrales, Luis; Campos-Parra, Alma Delia; Sánchez-Reyes, Roberto; Amieva-Rivera, Eduardo; Rodríguez, July; Vargas, Carlos; Carranza, Hernán; Otero, Jorge; Karachaliou, Nikki; Astudillo, Horacio; Rosell, Rafael; CLICaP, 1
• Is Part Of: Lung cancer. Volume 87:Issue 2(2015:Feb.)
• Page Start: 169
• Page End: 175
• Publication Date: 2015-02
• Subjects: Lungs -- Cancer -- Periodicals; Lung Neoplasms -- Abstracts; Lung Neoplasms -- Periodicals; Poumons -- Cancer -- Périodiques; Lungs -- Cancer; Periodicals; Electronic journals; Electronic journals; 616.99424
• DOI: 10.1016/j.lungcan.2014.12.009
• Languages: English
• ISSNs: 0169-5002

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">NSCLC patients with common <italic>EGFR</italic> mutations had higher response rates, PFS and OS to EGFR-TKIs than those with rare EGFR mutations.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">High-grade adenocarcinoma histology is associated with rare mutations.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Females have better PFS in response to EGFR-TKI in NSCLC bearing EGFR mutations.</p> </list-item> </list> </p> </sec> </abstract>