Biologicals, platelet apoptosis and human diseases: An outlook. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Thushara, R.M.; Hemshekhar, M.; Basappa; Kemparaju, K.; Rangappa, K.S.; Girish, K.S.
• Is Part Of: Critical reviews in oncology/hematology. Volume 93:Issue 3(2015)
• Page Start: 149
• Page End: 158
• Publication Date: 2015-03
• Subjects: Oncology -- Periodicals; Hematology -- Periodicals; 616.994
• DOI: 10.1016/j.critrevonc.2014.11.002
• Languages: English
• ISSNs: 1040-8428

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Platelets play a major role in health and disease including heart diseases and cancer.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Commonly used biologicals induce increased platelet apoptosis and thrombocytopenia.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Increased platelet apoptosis causes excess microparticle formation which is dangerous.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Side-effects of biologicals on platelets and the consequences are often neglected.</p> </list-item> <list-item id="lsti0025"> <label></label> <p id="par0025">There is a need to overcome side-effects of proapoptotic drugs via auxiliary therapy.</p> </list-item> </list> </p> </sec> </abstract>