In vivo model for mastocytosis: A comparative review. Issue 3 (March 2015)

• Record Type: Journal Article
• Authors: Ranieri, Girolamo; Marech, Ilaria; Pantaleo, Marianna; Piccinno, Mariagrazia; Roncetti, Maria; Mutinati, Maddalena; Rizzo, Annalisa; Gadaleta, Cosmo Damiano; Introna, Marcello; Patruno, Rosa; Sciorsci, Raffaele Luigi
• Is Part Of: Critical reviews in oncology/hematology. Volume 93:Issue 3(2015)
• Page Start: 159
• Page End: 169
• Publication Date: 2015-03
• Subjects: Oncology -- Periodicals; Hematology -- Periodicals; 616.994
• DOI: 10.1016/j.critrevonc.2014.10.010
• Languages: English
• ISSNs: 1040-8428

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">In <italic>vivo</italic> models of mast cell tumors (CMCTs) could represent a valid model to study human mastocytosis.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">We have focused on human mastocytosis in terms of: (i) epidemiology and classification; (ii) pathogenesis at molecular levels; (iii) clinical presentation.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">We have summarized animal models useful to study neoplastic MC disorders.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">We have revised therapeutic approaches mostly common in human and canine MCTs and novel tyrosine kinase inhibitors approved for CMCTs and translated in human clinical trials.</p> </list-item> </list> </p> </sec> </abstract>