Microstructural and mechanical characterization of scarred vocal folds. Issue 4 (26th February 2015)

• Record Type: Journal Article
• Authors: Heris, Hossein K.; Miri, Amir K.; Ghattamaneni, Nageswara R.; Li, Nicole Y.K.; Thibeault, Susan L.; Wiseman, Paul W.; Mongeau, Luc
• Is Part Of: Journal of biomechanics. Volume 48:Issue 4(2015)
• Page Start: 708
• Page End: 711
• Publication Date: 2015-02-26
• Subjects: Animal mechanics -- Periodicals; Biomechanics -- Periodicals; Biomechanics -- Periodicals; Mécanique animale -- Périodiques; Biomécanique -- Périodiques; Electronic journals; 571.4305
• DOI: 10.1016/j.jbiomech.2015.01.014
• Languages: English
• ISSNs: 0021-9290

Abstract

<abstract abstract-type="author" id="ab0005"> <title id="sect0005">Abstract</title> <sec> <p id="sp0025">The goal of this study was to characterize the vocal folds microstructure and elasticity using nonlinear laser scanning microscopy and atomic force microscopy-based indentation, respectively. As a pilot study, the vocal folds of fourteen rats were unilaterally injured by full removal of lamina propria; the uninjured folds of the same animals served as controls. The area fraction of collagen fibrils was found to be greater in scarred tissues two months after injury than the uninjured controls. A novel mathematical model was also proposed to relate collagen concentration and tissue bulk modulus. This work presents a first step towards systematic investigation of microstructural and mechanical characteristics in scarred vocal fold tissue.</p> </sec> </abstract>