Use of a high b‐value for diffusion weighted imaging of peritumoral regions to differentiate high‐grade gliomas and solitary metastases. Issue 1 (15th September 2014)

• Record Type: Journal Article
• Authors: Han, Chengkun; Huang, Shumin; Guo, Jianfeng; Zhuang, Xiongjie; Han, Haiwei
• Is Part Of: Journal of magnetic resonance imaging. Volume 42:Issue 1(2015)
• Page Start: 80
• Page End: 86
• Publication Date: 2014-09-15
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24747
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24747-sec-0001" sec-type="section"> <title>Background</title> <p>To determine whether apparent diffusion coefficient (ADC) values obtained using a b‐value of 3000 s/mm<sup>2</sup> can be used to differentiate high‐grade glioma (HGG) from solitary metastases (SM).</p> </sec> <sec id="jmri24747-sec-0002" sec-type="section"> <title>Methods</title> <p>Forty patients underwent conventional magnetic resonance imaging (MRI) and standard and high b‐value diffusion‐weighted imaging (DWI). Minimum, maximum, and mean ADC values (ADC<sub>MIN</sub>, ADC<sub>MAX</sub>, and ADC<sub>MEAN</sub>, respectively) were measured from ADC maps obtained for the two b‐values for each subject. ADC ratios were also measured. A receiver operating characteristic (ROC) curve analysis was used to determine the cutoff ADC value for distinguishing between HGG and SM.</p> </sec> <sec id="jmri24747-sec-0003" sec-type="section"> <title>Results</title> <p>All ADC values for the peritumoral region of the HGGs examined were lower than those for the SM. Furthermore, a larger statistical difference was observed for ADC<sub>MIN</sub>, ADC<sub>MAX</sub>, and ADC<sub>MEAN</sub> values at a b‐value of 3000 s/mm<sup>2</sup> versus 1000 s/mm<sup>2</sup> (<italic>P</italic> < 0.0001, <italic>P</italic> = 0.0010, and <italic>P</italic> = 0.0001 versus <italic>P</italic> = 0.0001, 0.0030, and 0.0002, respectively). A discriminant analysis identified the greatest log likelihood for the ADC<sub>MIN</sub> values obtained at a b‐value of 3000 s/mm<sup>2</sup>, and the cutoff value for differentiating HGG and SM was 0.890 × 10<sup>−3</sup> mm/s<sup>2</sup>.</p> </sec> <sec id="jmri24747-sec-0004" sec-type="section"> <title>Conclusion</title> <p>ADC values from DWI using a high b‐value were found to distinguish HGG and SM. The lowest degree of overlap was obtained when an ADC<sub>MIN</sub> value was obtained at a b‐value of 3000 s/mm<sup>2</sup>. <bold>J. Magn. Reson. Imaging 2015;42:80–86</bold>. © <bold>2014 Wiley Periodicals, Inc</bold>.</p> </sec> </abstract>