Gene Delivery: Tumor Intracellular‐Environment Responsive Materials Shielded Nano‐Complexes for Highly Efficient Light‐Triggered Gene Delivery without Cargo Gene Damage (Adv. Funct. Mater. 23/2015). (June 2015)

• Record Type: Journal Article
• Authors: Park, Sin‐jung; Park, Wooram; Na, Kun
• Is Part Of: Advanced functional materials. Volume 25:Number 23(2015)
• Page Start: 3615
• Page End: 3615
• Publication Date: 2015-06
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adfm.201570155
• Languages: English
• ISSNs: 1616-301X

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adfm201570155-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p>On page 3472, K. Na and co‐workers report highly efficient photo‐triggered gene expression without damage to the gene from reactive oxygen species by taking advantage of the endo‐lysosomal pH‐sensitive de‐shielding ability of the pH‐responsive shielding material incorporated in the gene complexes. Importantly, this newly developed gene delivery system also resolves the tissue penetration issue in drug delivery systems by photo‐mediated breaking down the extracellular matrix. <graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjzsk78wg" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>