Preferential Enrichment of DL‐Leucine Using Cocrystal Formation With Oxalic Acid Under Nonequilibrium Crystallization Conditions. Issue 7 (13th February 2015)

• Record Type: Journal Article
• Authors: Manoj, Kochunnoonny; Takahashi, Hiroki; Morita, Yoko; Gonnade, Rajesh G.; Iwama, Sekai; Tsue, Hirohito; Tamura, Rui
• Is Part Of: Chirality. Volume 27:Issue 7(2015)
• Page Start: 405
• Page End: 410
• Publication Date: 2015-02-13
• Subjects: Chirality -- Periodicals; Pharmaceutical chemistry -- Periodicals; 541.22
• DOI: 10.1002/chir.22431
• Languages: English
• ISSNs: 0899-0042

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <p>By utilizing the preferential enrichment (PE) technique, we achieved an improved enantiomeric resolution of <sc>DL</sc>‐leucine (Leu) using a 1:1 cocrystal (<sc>DL</sc>‐<bold>1</bold>) of <sc>DL</sc>‐Leu and oxalic acid. The crystal structure analysis of <sc>DL</sc>‐<bold>1</bold> indicated the occurrence of a novel type of phase transition and subsequent preferential redissolution of one enantiomer from the resulting crystals into solution. <italic>Chirality 27:405–410 2015</italic>. © 2015 Wiley Periodicals, Inc.</p> </abstract>