Elevation of C-reactive protein during the luteal phase in healthy adolescents. (April 2015)

• Record Type: Journal Article
• Authors: Merino, Paulina M.; Martínez, Daniela; Iñiguez, German; Lopez, Patricia; Cassorla, Fernando; Perez-Bravo, Francisco; Codner, Ethel
• Is Part Of: Gynecological endocrinology. Volume 31:Number 4(2015:Apr.)
• Page Start: 260
• Page End: 263
• Publication Date: 2015-04
• Subjects: Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.3109/09513590.2014.982086
• Languages: English
• ISSNs: 0951-3590

Abstract

<abstract> <title>Abstract</title> <p> <italic>Introduction</italic>: Variations in inflammatory markers have been reported in adult women during the luteal phase, but whether these findings are observed during adolescence is unknown. We postulate that higher ultrasensitive C-reactive protein (usCRP) and lower 2-hydroxyestrone (2OHE) levels, an estrogen metabolite with cardioprotective actions, are present during the luteal phase in young women.</p> <p> <italic>Aim</italic>: To evaluate usCRP levels during the menstrual cycle and to determine its association with 2OHE and 16α-hydroxyestrone (16OHE) in adolescents.</p> <p> <italic>Methods</italic>: Healthy postmenarcheal adolescents (<italic>N</italic> = 37) were studied during one menstrual cycle in follicular phase (FP) and luteal phase-like period (LP-L).</p> <p> <italic>Results</italic>: Elevations in usCRP levels in the LP-L were observed in the entire group and in anovulatory cycles (1.9 ± 1.1 mg/L in FP to 2.5 ± 1.8 mg/L in LP-L; <italic>p</italic> < 0.0001). Increases in estrone, estradiol, free and bioavailable estradiol, testosterone, usCRP and 2OHE levels were observed in LP-L compared with FP (<italic>p</italic> < 0.01), with a borderline elevation in IFG-I levels (<italic>p</italic> = 0.06).</p> <p> <italic>Conclusions</italic>: We report an elevation of usCRP and 2OHE levels during the luteal phase in healthy adolescents. Elevations of this inflammatory marker in anovulatory adolescents without an increase in 2OHE may play a role in metabolic risks associated with chronic anovulation.</p> </abstract>