TTF‐1 and napsin A on cell blocks and supernatants of pleural fluids for labeling malignant effusions. Issue 5 (14th April 2015)

• Record Type: Journal Article
• Authors: Porcel, José M.; Palma, Rosa; Bielsa, Silvia; Esquerda, Aureli; Gatius, Sonia; Matias‐Guiu, Xavier; Salud, Antonieta
• Is Part Of: Respirology. Volume 20:Issue 5(2015)
• Page Start: 831
• Page End: 833
• Publication Date: 2015-04-14
• Subjects: Respiratory organs -- Diseases -- Periodicals; Respiratory organs -- Periodicals; 612.2
• DOI: 10.1111/resp.12543
• Languages: English
• ISSNs: 1323-7799

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p>In this retrospective study of 80 pleural effusions, the combination of thyroid transcription factor 1 (TTF‐1) and napsin A immunostaining on fluid cell blocks was positive in 80% of lung adenocarcinomas. Although measuring TTF‐1 pleural fluid concentrations was of no value, quantification of napsin A levels allowed the identification of one third of the double‐negative stained lung adenocarcinomas, with an overall accuracy similar to classical tumour markers for malignant–benign discrimination (sensitivity 40%, specificity 100%).</p> </abstract>