Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder. Issue 7 (30th November 2013)

• Record Type: Journal Article
• Authors: Junqueira‐Neto, Susana; Vieira, Filipa Q.; Montezuma, Diana; Costa, Natália R.; Antunes, Luís; Baptista, Tiago; Oliveira, Ana Isabel; Graça, Inês; Rodrigues, Ângelo; Magalhães, José S.; Oliveira, Jorge; Henrique, Rui; Jerónimo, Carmen
• Is Part Of: Molecular carcinogenesis. Volume 54:Issue 7(2015:Jul.)
• Page Start: 523
• Page End: 531
• Publication Date: 2013-11-30
• Subjects: Carcinogenesis -- Molecular aspects -- Periodicals; 616.994071
• DOI: 10.1002/mc.22117
• Languages: English
• ISSNs: 0899-1987

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>ABSTRACT</title> <sec id="mc22117-sec-0001" sec-type="section"> <p>Deregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. Increased HDAC3 levels were associated with improved patient survival. SiRNA experiments showed decrease cell viability and motility, and increased apoptosis. We concluded that class I HDACs play an important role in bladder carcinogenesis through deregulation of proliferation, migration and apoptosis, constituting putative therapeutic targets. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>