Frontispiece: Divergent Synthesis of Aeruginosins Based on a C(sp3)H Activation Strategy. Issue 26 (22nd June 2015)

• Record Type: Journal Article
• Authors: Dailler, David; Danoun, Grégory; Ourri, Benjamin; Baudoin, Olivier
• Is Part Of: Chemistry. Volume 21:Issue 26(2015)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2015-06-22
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201582662
• Languages: English
• ISSNs: 0947-6539

Abstract

<abstract abstract-type="graphical" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Marine Natural Products</bold> Aeruginosins are marine natural products that have been isolated from sponges and cyanobacterial water blooms. Among these, aeruginosin 298A, 98A–C, and 101 have shown potent in vitro inhibition of various serine proteases, including thrombin and trypsin. In their Full Paper on <ext-link ext-link-type="doi" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink">page 9370 ff.</ext-link>, O. Baudoin et al. describe the total synthesis of aeruginosins 98A–C and 298A by the use of two different Pd‐catalyzed C(sp³)H activation reactions, with aeruginosin 298A synthesized on an unprecedentedly large scale.<graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgjwxhmjhk" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></p> </abstract>