Withania somnifera (Ashwagandha) in neurobehavioural disorders induced by brain oxidative stress in rodents: a systematic review and meta‐analysis. (1st April 2015)

• Record Type: Journal Article
• Authors: Durg, Sharanbasappa; Dhadde, Shivsharan B.; Vandal, Ravichandra; Shivakumar, Badamaranahalli S.; Charan, Chabbanahalli S.
• Is Part Of: Journal of pharmacy and pharmacology. Volume 67:Number 7(2015:Jul.)
• Page Start: 879
• Page End: 899
• Publication Date: 2015-04-01
• Subjects: Pharmacy -- Periodicals; Pharmacology -- Periodicals; 615.1
• DOI: 10.1111/jphp.12398
• Languages: English
• ISSNs: 0022-3573

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="jphp12398-sec-0001" sec-type="section"> <title>Objectives</title> <p> <italic>W</italic> <italic>ithania somnifera</italic> has been in use for several thousand years in Ayurveda to treat various neurological disorders. There is, however, not much scientific data on its protective role in neuronal pathology specifically against brain oxidative stress. Hence, an attempt is made in this work for systematic review and meta‐analysis of <italic>W</italic><italic>. somnifera</italic> on neurobehavioural disorders induced by brain oxidative stress in rodents.</p> </sec> <sec id="jphp12398-sec-1001" sec-type="section"> <title>Methods</title> <p>A systematic search of the effect of <italic>W</italic><italic>. somnifera</italic> on brain oxidative stress‐induced neuronal pathology was performed using electronic databases. The systematic review was performed on neurobehavioural parameters, whereas meta‐analysis of <italic>W</italic><italic>. somnifera</italic> effect was done on oxidative stress markers (superoxide dismutase, catalase, glutathione peroxidase, glutathione and lipid peroxidation), nitrite, protein carbonyl, AchE, ChAT and Ach of rodent brain. Data were analysed using Review Manager Software.</p> </sec> <sec id="jphp12398-sec-1002" sec-type="section"> <title>Key findings</title> <p>Twenty‐eight studies were selected based upon the inclusion and exclusion criteria. <italic>W</italic><italic>. somnifera</italic> appreciably inhibited the neurological abnormalities due to oxidative stress in rodent brain produced by different physical and chemical stimuli. <italic>W</italic><italic>. somnifera</italic> also significantly restored the altered oxidative and other stress markers in different parts of rodent brain.</p> </sec> <sec id="jphp12398-sec-0003" sec-type="section"> <title>Summary</title> <p>The systematic review provides scientific evidence for the traditional claim of <italic>W</italic><italic>. somnifera</italic> use in different neurological aliments. However, future clinical trials are mandated to establish the therapeutic efficacy and safety in human beings.</p> </sec> </abstract>