Incidence of cervical lymph node metastasis and its association with outcomes in patients with adenoid cystic carcinoma. An international collaborative study. Issue 7 (24th July 2014)

• Record Type: Journal Article
• Authors: Amit, Moran; Binenbaum, Yoav; Sharma, Kanika; Ramer, Naomi; Ramer, Ilana; Agbetoba, Abib; Glick, Joelle; Yang, Xinjie; Lei, Delin; Bjørndal, Kristine; Godballe, Christian; Mücke, Thomas; Wolff, Klaus‐Dietrich; Fliss, Dan; Eckardt, André M.; Copelli, Chiara; Sesenna, Enrico; Palmer, Frank; Ganly, Ian; Patel, Snehal; Gil, Ziv
• Is Part Of: Head & neck. Volume 37:Issue 7(2015:Jul.)
• Page Start: 1032
• Page End: 1037
• Publication Date: 2014-07-24
• Subjects: Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.23711
• Languages: English
• ISSNs: 1043-3074

Abstract

<abstract abstract-type="main"> <title>Abstract</title> <sec id="hed23711-sec-0001" sec-type="section"> <title>Background</title> <p>The patterns of regional metastasis in adenoid cystic carcinoma (ACC) of the head and neck and its association with outcome is not established.</p> </sec> <sec id="hed23711-sec-0002" sec-type="section"> <title>Methods</title> <p>We conducted a retrospective multicentered multivariate analysis of 270 patients who underwent neck dissection.</p> </sec> <sec id="hed23711-sec-0003" sec-type="section"> <title>Results</title> <p>The incidence rate of neck metastases was 29%. The rate observed in the oral cavity is 37%, and in the major salivary glands is 19% (<italic>p</italic> = .001). The rate of occult nodal metastases was 17%. Overall 5‐year survival rates were 44% in patients undergoing therapeutic neck dissections, and 65% and 73% among those undergoing elective neck dissections, with and without nodal metastases, respectively (<italic>p</italic> = .017). Multivariate analysis revealed that the primary site, nodal classification, and margin status were independent predictors of survival.</p> </sec> <sec id="hed23711-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Our findings support the consideration of elective neck treatment in patients with ACC of the oral cavity. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1032–1037, 2015</p> </sec> </abstract>