Association of angiopoietin‐1, angiopoietin‐2 and caspase‐5 polymorphisms with psoriasis vulgaris. (8th March 2015)

• Record Type: Journal Article
• Authors: He, L.; Dang, L.; Zhou, J.; Bai, J.; Li, Y.‐Z.
• Is Part Of: Clinical and experimental dermatology. Volume 40:Number 5(2015)
• Page Start: 556
• Page End: 563
• Publication Date: 2015-03-08
• Subjects: Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/ced.12550
• Languages: English
• ISSNs: 0307-6938

Abstract

<abstract abstract-type="main" id="ced12550-abs-0001"> <title>Summary</title> <sec id="ced12550-sec-0001" sec-type="section"> <title>Background</title> <p>Psoriasis involves a multifaceted interplay of keratinocytes, blood vessels, immune system mediators and expressed genes.</p> </sec> <sec id="ced12550-sec-0002" sec-type="section"> <title>Aim</title> <p>To determine whether genetic polymorphisms in the angiopoietin‐1 (<italic>ANGPT1</italic>), angiopoietin‐2 (<italic>ANGPT2</italic>) and caspase‐5 (<italic>CASP5</italic>) genes are associated with an increased risk of developing psoriasis vulgaris (PV) in a Han population in northeastern China.</p> </sec> <sec id="ced12550-sec-0003" sec-type="section"> <title>Methods</title> <p>We analysed single nucleotide polymorphisms of <italic>ANGPT1</italic> (rs2507800, rs1954727 and rs1010824), <italic>ANGPT2</italic> (rs3739390, rs2442598 and rs1868554) and caspase‐5 (rs507879, rs518604 and rs523104) in 343 patients with PV and 347 healthy controls (HCs) by the SNaPshot method, and evaluated the risk for psoriasis conferred by the individual polymorphisms and haplotypes.</p> </sec> <sec id="ced12550-sec-0004" sec-type="section"> <title>Results</title> <p>The rs2442598 polymorphism of <italic>ANGPT2</italic> was significantly associated with PV. The CT+TT genotype was present at an increased frequency in patients with PV (adjusted OR = 1.45, 95% CI 1.04–2.03, <italic>P</italic> = 0.03). However, the distribution of the other genotypes (rs2507800, rs1954727 and rs1010824 of <italic>ANGPT1</italic>; rs3739390 and rs1868554 of <italic>ANGPT2</italic>; and rs507879, rs518604 and rs523104 of caspase‐5) was not significantly different between patients with PV and the HCs. Furthermore, none of the genes in the haplotype‐based analysis showed any association with psoriasis risk.</p> </sec> <sec id="ced12550-sec-0005" sec-type="section"> <title>Conclusions</title> <p>Our data suggest that <italic>ANGPT2</italic> variants may be involved in PV risk in a Han population in northeastern China.</p> </sec> </abstract>