Effects of Antitumor Drug Sorafenib on Chick Embryo Development. Issue 7 (17th April 2015)
- Record Type:
- Journal Article
- Title:
- Effects of Antitumor Drug Sorafenib on Chick Embryo Development. Issue 7 (17th April 2015)
- Main Title:
- Effects of Antitumor Drug Sorafenib on Chick Embryo Development
- Authors:
- Cheng, Yi‐Sen
Wang, Xiao‐Yu
Wang, Guang
Li, Yan
Chen, Yue‐Lei
Chuai, Man‐li
Lee, Kenneth Ka Ho
Ding, Xiao‐Yan
Yang, Xue‐song - Abstract:
- <abstract abstract-type="main"> <title>ABSTRACT</title> <p>Sorafenib has been used as an oral anti‐cancer drug because of its ability to inhibit tumor growth. However, the pharmacological effect of sorafenib is still the lack of <italic>in vivo</italic> experimental evidence. Tumor and embryonic cells share some similar features, so we investigated the effects of sorafenib on the development of gastrulating chick embryos. We found that sorafenib exposure was markedly attributed to the number of embryonic cell in proliferation and apoptosis. We also detected sorafenib significantly interfered with epithelial‐mesenchymal transition (EMT). Furthermore, sorafenib treatment impaired the production and migration of neural crest cells. Anat Rec, 298:1271–1281, 2015. © 2015 Wiley Periodicals, Inc.</p> </abstract>
- Is Part Of:
- Anatomical record. Volume 298:Issue 7(2015:Jul.)
- Journal:
- Anatomical record
- Issue:
- Volume 298:Issue 7(2015:Jul.)
- Issue Display:
- Volume 298, Issue 7 (2015)
- Year:
- 2015
- Volume:
- 298
- Issue:
- 7
- Issue Sort Value:
- 2015-0298-0007-0000
- Page Start:
- 1271
- Page End:
- 1281
- Publication Date:
- 2015-04-17
- Subjects:
- Anatomy -- Periodicals
Evolution (Biology) -- Periodicals
Morphology -- Periodicals
571.3 - Journal URLs:
- http://www3.interscience.wiley.com/cgi-bin/jhome/113463905 ↗
http://onlinelibrary.wiley.com/journal/10.1002/(ISSN)1932-8494 ↗
http://onlinelibrary.wiley.com/ ↗ - DOI:
- 10.1002/ar.23155 ↗
- Languages:
- English
- ISSNs:
- 1932-8486
- Deposit Type:
- Legaldeposit
- View Content:
- Available online (eLD content is only available in our Reading Rooms) ↗
- Physical Locations:
- British Library DSC - 0898.005000
British Library DSC - BLDSS-3PM
British Library HMNTS - ELD Digital store - Ingest File:
- 3911.xml