Advances in research of the neuroprotective mechanisms of cerebral ischemic postconditioning. (4th March 2015)

• Record Type: Journal Article
• Authors: Ma, Xu-Dong; Song, Jin-Ning; Zhang, Ming; An, Ji-Yang; Zhao, Yong-Lin; Zhang, Bin-fei
• Is Part Of: International journal of neuroscience. Volume 125:Number 3(2015:Mar.)
• Page Start: 161
• Page End: 169
• Publication Date: 2015-03-04
• Subjects: Nervous system -- Periodicals; 612.805
• DOI: 10.3109/00207454.2014.917413
• Languages: English
• ISSNs: 0020-7454

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Ischemic postconditioning refers to controlling reperfusion blood flow during reperfusion after ischemia, which can induce an endogenous neuroprotective effect and reduce ischemia-reperfusion injury. Activation of endogenous neuroprotective mechanisms plays a key role in protecting against brain ischemia-reperfusion injury. The mechanisms of cerebral ischemic postconditioning are not completely clear, and the following aspects may be involved: downregulation of oxidative stress, attenuating mitochondrial dysfunction, attenuating endoplasmic reticulum stress, accelerating the elimination of glutamate, increasing rCBF, inhibiting apoptosis, inhibiting autophagy, and regulating signal transduction.</p> </abstract>