Dietary total antioxidant capacity is associated with leukocyte telomere length in a children and adolescent population. Issue 4 (August 2015)

• Record Type: Journal Article
• Authors: García-Calzón, Sonia; Moleres, Adriana; Martínez-González, Miguel A.; Martínez, J. Alfredo; Zalba, Guillermo; Marti, Amelia; GENOI members, 1
• Is Part Of: Clinical nutrition. Volume 34:Issue 4(2015:Aug.)
• Page Start: 694
• Page End: 699
• Publication Date: 2015-08
• Subjects: Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2014.07.015
• Languages: English
• ISSNs: 0261-5614

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Summary</title> <sec> <title id="sectitle0015">Background & aims</title> <p id="abspara0010">Oxidative stress and inflammation seem to be potential underlying mechanisms for telomere attrition. A lack of specific antioxidants is believed to increase free radical damage and a greater risk for telomere shortening. Our aim was to evaluate the relationship between diet and leukocyte telomere length in a cross-sectional study of children and adolescents. We hypothesized that dietary total antioxidant capacity would be positively associated with telomere length.</p> </sec> <sec> <title id="sectitle0020">Methods</title> <p id="abspara0015">Telomere length was measured by quantitative real-time polymerase chain reaction in 287 participants (55% males, 6–18 years), who were randomly selected from the GENOI study.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">A positive correlation between dietary total antioxidant capacity and telomere length (<italic>r</italic> = 0.157, <italic>p</italic> = 0.007) was found after adjustment for age and energy intake. However, higher white bread consumption was associated with shorter telomeres (<italic>β</italic> = −0.204, <italic>p</italic> = 0.002) in fully-adjusted models. Interestingly, those individuals who had simultaneously higher dietary total antioxidant capacity and lower white bread consumption significantly presented the longest telomeres. Moreover, the multivariable-adjusted odds ratio for very short telomeres was 0.30 for dietary total antioxidant capacity (<italic>p</italic> = 0.023) and 1.37 for white bread (<italic>p</italic> = 0.025).</p> </sec> <sec> <title id="sectitle0030">Conclusion</title> <p id="abspara0025">It was concluded that longer telomeres were associated with higher dietary total antioxidant capacity and lower white bread consumption in Spanish children and adolescents. These findings might open a new line of investigation about the potential role of an antioxidant diet in maintaining telomere length.</p> </sec> </abstract>