Calcium plus vitamin D supplementation affects glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome. Issue 4 (August 2015)

• Record Type: Journal Article
• Authors: Asemi, Zatollah; Foroozanfard, Fatemeh; Hashemi, Teibeh; Bahmani, Fereshteh; Jamilian, Mehri; Esmaillzadeh, Ahmad
• Is Part Of: Clinical nutrition. Volume 34:Issue 4(2015:Aug.)
• Page Start: 586
• Page End: 592
• Publication Date: 2015-08
• Subjects: Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2014.09.015
• Languages: English
• ISSNs: 0261-5614

Abstract

<abstract xml:lang="en" abstract-type="author" id="abs0010"> <title id="sectitle0010">Summary</title> <sec> <title id="sectitle0015">Background & aims</title> <p id="abspara0010">Few studies have examined the effects of calcium plus vitamin D supplementation on glucose metabolism and lipid concentrations in overweight and obese vitamin D deficient women with polycystic ovary syndrome (PCOS). This study was conducted to determine the effects of calcium plus vitamin D supplementation on glucose metabolism and lipid concentrations among overweight and obese vitamin D deficient women with PCOS.</p> </sec> <sec> <title id="sectitle0020">Methods</title> <p id="abspara0015">This randomized double-blind placebo-controlled clinical trial was conducted among 104 overweight and obese vitamin D deficient women diagnosed with PCOS. Participants were randomly assigned into four groups to receive: 1) 1000 mg/d calcium + vitamin D placebo (<italic>n</italic> = 26); 2) 50, 000 IU/wk vitamin D + calcium placebo (<italic>n</italic> = 26); 3) 1000 mg calcium/d + 50, 000 IU/wk vitamin D (<italic>n</italic> = 26) and 4) calcium placebo + vitamin D placebo (<italic>n</italic> = 26) for 8 weeks. Fasting blood samples were taken at baseline and after 8 weeks' intervention to measure glucose metabolism and lipid concentrations.</p> </sec> <sec> <title id="sectitle0025">Results</title> <p id="abspara0020">Calcium-vitamin D co-supplementation resulted in higher levels of serum calcium (<italic>P</italic> = 0.002) and vitamin D (<italic>P</italic> < 0.001) compared with other groups. Co-supplementation, compared with other groups, led to decreased serum insulin levels (<italic>P</italic> = 0.03), homeostasis model of assessment-insulin resistance (HOMA-IR) score (<italic>P</italic> = 0.04) and a significant rise in quantitative insulin sensitivity check index (QUICKI) (<italic>P</italic> = 0.001). Furthermore, a significant decrease in serum triglycerides (<italic>P</italic> = 0.02) and VLDL-cholesterol levels (<italic>P</italic> = 0.02) was seen following the administration of calcium plus vitamin D supplements compared with the other groups. Co-supplementation with calcium and vitamin D had no significant effects on FPG, total-, LDL-, HDL-, and non-HDL-cholesterol levels.</p> </sec> <sec> <title id="sectitle0030">Conclusions</title> <p id="abspara0025">In conclusion, calcium plus vitamin D supplementation for eight weeks among vitamin D deficient women with PCOS had beneficial effects on serum insulin levels, HOMA-IR, QUICKI, serum triglycerides and VLDL-cholesterol levels, but it did not affect FPG and other lipid profiles.</p> <p id="abspara0030">Clinical registration number<ext-link ext-link-type="unknown" id="intref0010" xlink:type="simple" xlink:href="http://www.irct.ir" xmlns:xlink="http://www.w3.org/1999/xlink">www.irct.ir</ext-link>: <ext-link ext-link-type="unknown" id="intref0015" xlink:type="simple" xlink:href="ctgov:IRCT201309275623N10" xmlns:xlink="http://www.w3.org/1999/xlink">IRCT201309275623N10</ext-link></p> </sec> </abstract>