Preclinical refinements of a broadly protective VLP-based HPV vaccine targeting the minor capsid protein, L2. Issue 29 (26th June 2015)

• Record Type: Journal Article
• Authors: Tumban, Ebenezer; Muttil, Pavan; Escobar, Carolina Andrea A.; Peabody, Julianne; Wafula, Denis; Peabody, David S.; Chackerian, Bryce
• Is Part Of: Vaccine. Volume 33:Issue 29(2015)
• Page Start: 3346
• Page End: 3353
• Publication Date: 2015-06-26
• Subjects: Vaccines -- Periodicals; 615.372
• DOI: 10.1016/j.vaccine.2015.05.016
• Languages: English
• ISSNs: 0264-410X

Abstract

<abstract abstract-type="author-highlights" id="abs0005"> <title id="sect0005">Highlights</title> <sec> <p id="spar0005"> <list id="lis0005"> <list-item id="lsti0005"> <label></label> <p id="par0005">Virus-like particles displaying an HPV16 L2 peptide (16L2-MS2 VLPs) are highly immunogenic over a range of doses.</p> </list-item> <list-item id="lsti0010"> <label></label> <p id="par0010">Immune responses to 16L2-MS2 VLPs last over 18 months.</p> </list-item> <list-item id="lsti0015"> <label></label> <p id="par0015">Spray-drying L2 VLPs enhances their stability.</p> </list-item> <list-item id="lsti0020"> <label></label> <p id="par0020">Spray dried L2 VLPs stored over 7 months at room temperature are highly immunogenic and protective against HPV infections.</p> </list-item> </list> </p> </sec> </abstract>