Enantioselective Construction of 3‐Hydroxypiperidine Scaffolds by Sequential Action of Light and Rhodium upon N‐Allylglyoxylamides1. (7th May 2015)

• Record Type: Journal Article
• Authors: Ishida, Naoki; Nečas, David; Masuda, Yusuke; Murakami, Masahiro
• Is Part Of: Angewandte Chemie. Volume 127:Number 25(2015)
• Page Start: 7526
• Page End: 7529
• Publication Date: 2015-05-07
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201502584
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>3‐Hydroxypiperidine scaffolds were enantioselectively constructed in an atom‐economical way by sequential action of light and rhodium upon N‐allylglyoxylamides. In a formal sense, the allylic CH bond was selectively cleaved and enantioselectively added across the ketonic carbonyl group with migration of the double bond (carbonyl‐ene‐type reaction).</p> </abstract>