Reliable Quantitative SERS Analysis Facilitated by Core–Shell Nanoparticles with Embedded Internal Standards1. (4th May 2015)

• Record Type: Journal Article
• Authors: Shen, Wei; Lin, Xuan; Jiang, Chaoyang; Li, Chaoyu; Lin, Haixin; Huang, Jingtao; Wang, Shuo; Liu, Guokun; Yan, Xiaomei; Zhong, Qiling; Ren, Bin
• Is Part Of: Angewandte Chemie. Volume 127:Number 25(2015)
• Page Start: 7416
• Page End: 7420
• Publication Date: 2015-05-04
• Subjects: Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201502171
• Languages: English
• ISSNs: 0044-8249

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <p>Quantitative analysis is a great challenge in surface‐enhanced Raman scattering (SERS). Core‐molecule‐shell nanoparticles with two components in the molecular layer, a framework molecule to form the shell, and a probe molecule as a Raman internal standard, were rationally designed for quantitative SERS analysis. The signal of the embedded Raman probe provides effective feedback to correct the fluctuation of samples and measuring conditions. Meanwhile, target molecules with different affinities can be adsorbed onto the shell. The quantitative analysis of target molecules over a large concentration range has been demonstrated with a linear response of the relative SERS intensity versus the surface coverage, which has not been achieved by conventional SERS methods.</p> </abstract>