Identification of ribonucleotide reductase mutation causing temperature‐sensitivity of herpes simplex virus isolates from whitlow by deep sequencing. Issue 6 (22nd April 2015)

• Record Type: Journal Article
• Authors: Daikoku, Tohru; Oyama, Yukari; Yajima, Misako; Sekizuka, Tsuyoshi; Kuroda, Makoto; Shimada, Yuka; Takehara, Kazuhiko; Miwa, Naoko; Okuda, Tomoko; Sata, Tetsutaro; Shiraki, Kimiyasu
• Is Part Of: Clinical case reports. Volume 3:Issue 6(2015:Dec.)
• Page Start: 461
• Page End: 467
• Publication Date: 2015-04-22
• Subjects: Medicine -- Periodicals; 616.09
• DOI: 10.1002/ccr3.270
• Languages: English
• ISSNs: 2050-0904

Abstract

<abstract abstract-type="main" id="ccr3270-abs-0001"> <title>Key Clinical Message</title> <p>Herpes simplex virus 2 caused a genital ulcer, and a secondary herpetic whitlow appeared during acyclovir therapy. The secondary and recurrent whitlow isolates were acyclovir‐resistant and temperature‐sensitive in contrast to a genital isolate. We identified the ribonucleotide reductase mutation responsible for temperature‐sensitivity by deep‐sequencing analysis.</p> </abstract>